Eosinophils and respiratory disease

Respiratory burst of normal human eosinophils.

Oxidative metabolism of eosinophils has generally been studied in cells from patients with eosinophilia. We isolated eosinophils with purity of greater than 95% from normal donors. Oxygen metabolism of eosinophils and neutrophils was compared using O2-. production as a measure of the stimulus-induced respiratory burst. During 10 min of stimulation, using phorbol myristate acetate (PMA) or opson...

Aspirin-Exacerbated Respiratory Disease Cells: Implications in the Pathogenesis of Aspirin Activation of Eosinophils and Mast

BK Polyomavirus in Respiratory Specimens of Patients with Respiratory Disease

Background and Aims: The role of BK and JC polyomaviruses (BKV and JCV) in the causation of respiratory disease and the natural route of transmission has not well been established. The aim of study was to determine the prevalence of BK and JC viruses in 280 respiratory samples and evaluate their contribution to respiratory disease. Materials and Methods: PCR was used to screen specimens for BK...

Activated eosinophils in coeliac disease.

Cutting edge: Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced disease.

Respiratory syncytial virus (RSV) infection of BALB/c mice previously immunized with a recombinant vaccinia virus (vacv) expressing the attachment (G) protein of RSV (vacvG) results in pulmonary eosinophilia, which mimics the response of formalin-inactivated RSV-vaccinated children, as well as increased weight loss, clinical illness, and enhanced pause (Penh). We show that RSV infection of eosi...